Abbreviation:
PAMPA: Parallel Artificial Membrane Permeability Assay;
MDCK: Madin-Darby Canine Kidney Cells;
RRCK: Ralph Russ Canine Kidney Cells ;
ER: Efflux Ratio ;
Papp: Apparent Permeability;(Nožinić et al., 2010 ),
Peff: Effective Permeability.
(Rzepiela et al., 2022 )
Check the Molecular Descriptors Statistics
Molecular Descriptors Distrubution of All Entires
¹ AR = 3×AB/MRS. Where, AB denotes the total number of amide bonds (inclusive of NH and N-alkylated bonds),
each multiplied by three to account for the number atoms (-N-Cα-C-) forming each amide bond within the macrocyclic ring.
MRS represents the total number of atoms in the macrocyclic ring. AR returns a value between 0 and 1,
a value of 0 represents a non-peptide macrocycle, and 1 represent cyclic peptide.
(Feng et.al, 2024)
